N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester
1477949-42-0
278.4
C15H22N2O3
DMSO, Ethanol
-20°C
Santacruzamate A is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively). Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors. Potential therapeutic agent for breast cancer. Attenuates A fragment (Ab25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance4. Ameliorates Alzheimer’s disease-like pathology in mouse models.
Research or further manufacturing use only, not for food or drug use.
